How Much Do Puppy Shots Cost? | 2025 Puppy Vaccination Guide

How Much Are Puppy Shots in 2025? Welcoming a new puppy into your life is exciting, but it also comes with responsibilities. One of the most important being vaccinations. Puppy shots protect your furry friend from serious diseases and ensure a healthy start to life. If you’re a new pet parent, you may be wondering, How much do puppy shots cost? In this article, we’ll walk you through the average costs of puppy vaccinations, the types of shots your pup needs, and tips on how to save money without compromising care.

Why Are Puppy Shots Important?

Vaccinations play a vital role in preventing dangerous, potentially fatal diseases such as parvovirus, distemper, hepatitis, and rabies. Puppies are especially vulnerable because their immune systems are still developing. Without proper vaccinations, they are at risk when interacting with other pets, exploring outdoors, or even visiting the vet.

Vaccines work by stimulating your puppy’s immune system to recognize and fight off viruses and bacteria. While your puppy may experience mild side effects like slight soreness or tiredness, the long-term protection far outweighs any temporary discomfort.

What Shots Does a Puppy Need?

Most veterinarians recommend a series of core and non-core vaccinations for puppies. Here’s a typical schedule and breakdown of common vaccines:

Core Vaccines (Essential):

1. DHPP Vaccine (Distemper, Hepatitis, Parvovirus, Parainfluenza)

   • Given at 6–8 weeks, 10–12 weeks, and 14–16 weeks.

2. Rabies

   • Typically administered at 12–16 weeks, depending on state laws.

Non-Core Vaccines (Based on lifestyle or environment):

• Bordetella (Kennel Cough)

• Leptospirosis

• Lyme Disease

• Canine Influenza

Your vet will help you determine which non-core vaccines are appropriate based on where you live, your dog’s lifestyle, and any local disease outbreaks.

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How Much Do Puppy Shots Cost?

The cost of puppy vaccinations varies depending on your location, your choice of veterinary clinic, and whether you opt for a private practice, low-cost clinic, or animal shelter. Here’s a general cost estimate in the United States:

1. Core Vaccine Series (DHPP x 3 doses)

• $20 to $60 per shot

• Total: $60 to $180

2. Rabies Vaccine

• $15 to $40 (often includes a certificate and rabies tag)

• Total: $15 to $40

3. Bordetella Vaccine

• $20 to $50 (optional but often required for boarding and daycare)

• Total: $20 to $50

4. Leptospirosis Vaccine

• $25 to $50 (may be combined with DHPP as DHLPP)

• Total: $25 to $50

5. Lyme Disease Vaccine

• $25 to $60

• Total: $25 to $60

6. Canine Influenza Vaccine

• $30 to $70

• Total: $30 to $70

Quote: “Vaccinating your puppy is one of the most important investments you can make in their lifelong health. At Petworks, we believe preventive care isn’t just smart. It’s an act of love.” – Kevin Kinyon, Founder of Petworks

Estimated Total Cost for Puppy Shots

If you follow a typical vaccination schedule with only core shots, you can expect to pay between $100 and $220 for the first few months. If you choose to include all non-core vaccines, the cost can rise to $250–$500 or more during the first year.

Here’s a rough breakdown:

Annual Booster Shots and Ongoing Costs

After completing the initial puppy series, your dog will need booster shots to maintain immunity. Many core vaccines are given once every one to three years depending on the vaccine type and state laws. Budget an additional $75 to $200 annually for booster shots and checkups.

Ways to Save Money on Puppy Vaccinations

1. Low-Cost Clinics and Vaccine Events:
   Many animal shelters, pet supply stores (like Petco or Tractor Supply), and rescue organizations host low-cost vaccine clinics. You may be able to get all core shots for as little as $50–$75.

2. Vaccination Packages:
   Veterinary clinics often offer puppy wellness packages that include all core vaccines, deworming, and exams for a flat rate, often between $100 and $300.

3. Pet Insurance:
   Some pet insurance plans cover routine care, including vaccinations. Be sure to compare plans that include wellness coverage if you want reimbursement for preventive care.

4. Non-Profit Veterinary Clinics:
   Non-profit and community veterinary clinics often offer reduced-cost vaccinations to income-qualified pet owners. Search for “affordable pet vaccines near me” to see what’s available in your area.

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Are Puppy Shots Worth the Cost?

Absolutely. While puppy vaccines may feel like a large upfront cost, they’re far less expensive than treating diseases like parvo or distemper, which can cost thousands of dollars in emergency care and hospitalization. Vaccines offer peace of mind and long-term health protection for your puppy and others they come into contact with.

Questions to Ask Your Veterinarian

When booking your puppy’s first vaccination visit, ask your vet:

• Which vaccines are required by law in my state?

• What’s the recommended vaccine schedule for my breed and lifestyle?

• Are there any combination vaccines to reduce the number of shots?

• Can I purchase a puppy wellness package?

• Should I hire a puppy nutritionist to help with proper diets during and after puppy vaccinations have been given to my pup?

These questions will help you plan financially and ensure your puppy receives the proper care at the right time.

In 2021, Dr. Marty Goldstein DVM joined the pet care platform Petworks as an advisor in its Animal Nutrition care division. Dr Marty Nature’s Blend is on a mission to help your pets live their healthiest lives possible. Dr. Marty’s pet nutrition expertise and guidance has helped Petworks evolve and become the preeminent animal and pet nutrition consultation service for pet parents in North America.

In 2022, Blue Buffalo Founder Bill Bishop Jr. joined Petworks as Senior Advisor in our Animal Nutrition Care Division. Bill brings his extensive expertise in pet food innovation and business leadership. His guidance helps Petworks enhance our pet nutrition service offerings, helping to ensure that pet parents throughout the world receive trusted, science-backed nutritional support for their dogs, cats, and animals.