{"id":9806,"date":"2025-10-02T17:30:26","date_gmt":"2025-10-02T22:30:26","guid":{"rendered":"https:\/\/www.petworks.com\/articles\/?p=9806"},"modified":"2025-10-02T17:30:31","modified_gmt":"2025-10-02T22:30:31","slug":"hypercalcemia-in-cats","status":"publish","type":"post","link":"https:\/\/www.petworks.com\/articles\/hypercalcemia-in-cats\/","title":{"rendered":"What Are The Signs Of Hypercalcemia In Cats?"},"content":{"rendered":"<p data-pm-slice=\"1 1 []\">Understanding Hypercalcemia in Cats: Causes, Symptoms, Diagnosis, and Treatment. Hypercalcemia in cats is a condition characterized by elevated calcium levels in the bloodstream. While calcium is essential for various bodily functions, excessive levels can lead to serious health complications. Understanding the causes, symptoms, diagnosis, and treatment options for hypercalcemia is crucial for cat owners to ensure their feline companions receive appropriate care.<\/p>\n<p data-pm-slice=\"1 1 []\"><!--more--><\/p>\n<h3 data-pm-slice=\"1 1 []\"><strong>What Is Hypercalcemia?<\/strong><\/h3>\n<p>Hypercalcemia occurs when a cat\u2019s calcium levels exceed the normal range of approximately 8.5 to 11.0 mg\/dL. Persistent hypercalcemia can affect multiple organ systems, leading to kidney damage, cardiovascular issues, and neurological problems. The condition can be either primary or secondary to an underlying disease.<\/p>\n<h3 data-pm-slice=\"1 3 []\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-7515 size-full\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/01\/Petworks-Pet-Care-Service-Pro-Tips-e1736622469982.png\" alt=\"Hypercalcemia In Cats\" width=\"120\" height=\"120\" \/>Causes of Hypercalcemia in Cats<\/strong><\/h3>\n<p>Hypercalcemia in cats can arise from various medical conditions, including:<\/p>\n<ol start=\"1\" data-spread=\"false\">\n<li><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/11110384\/\"><strong>Idiopathic Hypercalcemia<\/strong><\/a><\/span> \u2013 The most common cause of hypercalcemia in cats, particularly in middle-aged and older felines. The exact cause remains unknown.<\/li>\n<li><strong>Chronic Kidney Disease (CKD)<\/strong> \u2013 Impaired kidney function can disrupt calcium and phosphorus balance, leading to hypercalcemia.<\/li>\n<li><strong>Cancer (Neoplasia)<\/strong> \u2013 Lymphoma, squamous cell carcinoma, and other malignancies can lead to elevated calcium levels.<\/li>\n<li><strong>Primary Hyperparathyroidism<\/strong> \u2013 A rare condition where the parathyroid glands produce excessive parathyroid hormone (PTH), increasing calcium absorption.<\/li>\n<li><strong>Vitamin D Toxicity<\/strong> \u2013 Ingestion of excessive vitamin D supplements, rodenticides, or certain human medications can cause dangerously high calcium levels.<\/li>\n<li><strong>Granulomatous Diseases<\/strong> \u2013 Infections or inflammatory conditions, such as fungal infections, can contribute to calcium imbalances.<\/li>\n<li><strong>Addison\u2019s Disease<\/strong> \u2013 Hypoadrenocorticism, a disorder of the adrenal glands, can be associated with hypercalcemia.<\/li>\n<\/ol>\n<h3 data-pm-slice=\"1 1 []\"><strong>Symptoms of Hypercalcemia in Cats<\/strong><\/h3>\n<p>The clinical signs of hypercalcemia vary depending on the severity and underlying cause. Common symptoms include:<\/p>\n<ul data-spread=\"false\">\n<li>Increased thirst (polydipsia) and urination (polyuria)<\/li>\n<li>Lethargy and weakness<\/li>\n<li>Decreased appetite (anorexia)<\/li>\n<li>Vomiting<\/li>\n<li>Constipation<\/li>\n<li>Weight loss<\/li>\n<li>Muscle tremors or twitching<\/li>\n<li>Depression or <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.petworks.com\/hire\/cat-behaviorist\">behavioral changes<\/a><\/span><\/li>\n<li>Increased risk of bladder stones due to excess calcium<\/li>\n<\/ul>\n<h3 data-start=\"244\" data-end=\"422\"><strong>Additional and Clinical Signs Of Hypercalcemia In Cats<\/strong><\/h3>\n<p data-start=\"244\" data-end=\"422\">The clinical signs of hypercalcemia depend on both its <strong data-start=\"299\" data-end=\"311\">severity<\/strong> and the <strong data-start=\"320\" data-end=\"340\">underlying cause<\/strong>. They may be subtle at first but become more pronounced as calcium levels rise:<\/p>\n<p data-start=\"424\" data-end=\"451\"><strong data-start=\"424\" data-end=\"449\">Urinary &amp; Renal Signs<\/strong><\/p>\n<ul data-start=\"452\" data-end=\"722\">\n<li data-start=\"452\" data-end=\"489\">\n<p data-start=\"454\" data-end=\"489\">Increased thirst (<strong data-start=\"472\" data-end=\"486\">polydipsia<\/strong>)<\/p>\n<\/li>\n<li data-start=\"490\" data-end=\"528\">\n<p data-start=\"492\" data-end=\"528\">Increased urination (<strong data-start=\"513\" data-end=\"525\">polyuria<\/strong>)<\/p>\n<\/li>\n<li data-start=\"529\" data-end=\"597\">\n<p data-start=\"531\" data-end=\"597\">Blood in urine (<strong data-start=\"547\" data-end=\"560\">hematuria<\/strong>) from bladder or kidney irritation<\/p>\n<\/li>\n<li data-start=\"598\" data-end=\"670\">\n<p data-start=\"600\" data-end=\"670\">Formation of <strong data-start=\"613\" data-end=\"657\">calcium oxalate bladder or kidney stones<\/strong> (uroliths)<\/p>\n<\/li>\n<li data-start=\"671\" data-end=\"722\">\n<p data-start=\"673\" data-end=\"722\">Possible urinary tract infections due to stones<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"724\" data-end=\"752\"><strong data-start=\"724\" data-end=\"750\">Gastrointestinal Signs<\/strong><\/p>\n<ul data-start=\"753\" data-end=\"911\">\n<li data-start=\"753\" data-end=\"788\">\n<p data-start=\"755\" data-end=\"788\">Reduced appetite (<strong data-start=\"773\" data-end=\"785\">anorexia<\/strong>)<\/p>\n<\/li>\n<li data-start=\"789\" data-end=\"812\">\n<p data-start=\"791\" data-end=\"812\">Nausea and drooling<\/p>\n<\/li>\n<li data-start=\"813\" data-end=\"869\">\n<p data-start=\"815\" data-end=\"869\">Vomiting (sometimes chronic, sometimes intermittent)<\/p>\n<\/li>\n<li data-start=\"870\" data-end=\"886\">\n<p data-start=\"872\" data-end=\"886\">Constipation<\/p>\n<\/li>\n<li data-start=\"887\" data-end=\"911\">\n<p data-start=\"889\" data-end=\"911\">Abdominal discomfort<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"913\" data-end=\"955\"><strong data-start=\"913\" data-end=\"953\">Musculoskeletal &amp; Neurological Signs<\/strong><\/p>\n<ul data-start=\"956\" data-end=\"1142\">\n<li data-start=\"956\" data-end=\"1003\">\n<p data-start=\"958\" data-end=\"1003\">Muscle weakness or reluctance to jump\/climb<\/p>\n<\/li>\n<li data-start=\"1004\" data-end=\"1047\">\n<p data-start=\"1006\" data-end=\"1047\">Muscle tremors, twitching, or stiffness<\/p>\n<\/li>\n<li data-start=\"1048\" data-end=\"1072\">\n<p data-start=\"1050\" data-end=\"1072\">Ataxia (wobbly gait)<\/p>\n<\/li>\n<li data-start=\"1073\" data-end=\"1103\">\n<p data-start=\"1075\" data-end=\"1103\">Seizures (in severe cases)<\/p>\n<\/li>\n<li data-start=\"1104\" data-end=\"1142\">\n<p data-start=\"1106\" data-end=\"1142\">Generalized lethargy or depression<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1144\" data-end=\"1176\"><strong data-start=\"1144\" data-end=\"1174\">Behavioral &amp; General Signs<\/strong><\/p>\n<ul data-start=\"1177\" data-end=\"1298\">\n<li data-start=\"1177\" data-end=\"1216\">\n<p data-start=\"1179\" data-end=\"1216\">Irritability or personality changes<\/p>\n<\/li>\n<li data-start=\"1217\" data-end=\"1248\">\n<p data-start=\"1219\" data-end=\"1248\">Decreased grooming behavior<\/p>\n<\/li>\n<li data-start=\"1249\" data-end=\"1298\">\n<p data-start=\"1251\" data-end=\"1298\">Weight loss and poor body condition over time<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1300\" data-end=\"1367\"><strong data-start=\"1300\" data-end=\"1324\">Cardiovascular Signs<\/strong> (with severe or prolonged hypercalcemia)<\/p>\n<ul data-start=\"1368\" data-end=\"1482\">\n<li data-start=\"1368\" data-end=\"1410\">\n<p data-start=\"1370\" data-end=\"1410\">High blood pressure (<strong data-start=\"1391\" data-end=\"1407\">hypertension<\/strong>)<\/p>\n<\/li>\n<li data-start=\"1411\" data-end=\"1452\">\n<p data-start=\"1413\" data-end=\"1452\">Irregular heartbeat (<strong data-start=\"1434\" data-end=\"1449\">arrhythmias<\/strong>)<\/p>\n<\/li>\n<li data-start=\"1453\" data-end=\"1482\">\n<p data-start=\"1455\" data-end=\"1482\">Collapse in extreme cases<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1489\" data-end=\"1752\">\u26a0\ufe0f Because these symptoms overlap with kidney disease, hyperthyroidism, cancer, and other feline conditions, <strong data-start=\"1598\" data-end=\"1655\">blood tests and urinalysis are required for diagnosis<\/strong>. Hypercalcemia should always be evaluated by a veterinarian to determine the underlying cause.<\/p>\n<h3 data-pm-slice=\"1 3 []\"><strong>Diagnosing Hypercalcemia in Cats<\/strong><\/h3>\n<p>Veterinarians diagnose hypercalcemia through a combination of physical examination, blood tests, and diagnostic imaging. The following steps are typically involved:<\/p>\n<ol start=\"1\" data-spread=\"false\">\n<li><strong>Blood Tests<\/strong> \u2013 A serum biochemistry panel measures total and ionized calcium levels, as well as kidney function and phosphorus levels.<\/li>\n<li><strong>Parathyroid Hormone (PTH) Test<\/strong> \u2013 Determines if hyperparathyroidism is the cause.<\/li>\n<li><strong>Vitamin D Testing<\/strong> \u2013 Identifies vitamin D toxicity.<\/li>\n<li><strong>Urinalysis<\/strong> \u2013 Checks for kidney function abnormalities or urinary stones.<\/li>\n<li><strong>Imaging (X-rays, Ultrasound)<\/strong> \u2013 Detects tumors, kidney disease, or bladder stones.<\/li>\n<li><strong>Bone Marrow Aspirate or Biopsy<\/strong> \u2013 In cases where lymphoma or other cancers are suspected.<\/li>\n<\/ol>\n<h3 data-pm-slice=\"1 3 []\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-7032 size-full\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/01\/Petworks-Pet-Care-Hedgehog.png\" alt=\"Hypercalcemia In Cats\" width=\"108\" height=\"69\" \/>Treatment Options for Hypercalcemia in Cats<\/strong><\/h3>\n<p>Treatment depends on the severity of hypercalcemia and its underlying cause. The primary goal is to reduce calcium levels while addressing the root issue.<\/p>\n<h4><strong>1. Fluid Therapy<\/strong><\/h4>\n<p>Intravenous (IV) fluid therapy is often the first line of treatment. Increasing fluid intake helps flush excess calcium from the bloodstream through the kidneys.<\/p>\n<h4><strong>2. Dietary Management<\/strong><\/h4>\n<p>A low-calcium, phosphorus-controlled diet may help manage chronic hypercalcemia, particularly in cats with idiopathic hypercalcemia or CKD.<\/p>\n<h4><strong>3. Medications<\/strong><\/h4>\n<p>Depending on the cause, different medications may be used:<\/p>\n<ul data-spread=\"false\">\n<li><strong>Bisphosphonates<\/strong> (e.g., alendronate) help reduce bone resorption and lower calcium levels.<\/li>\n<li><strong>Steroids<\/strong> (e.g., prednisone) may be prescribed for inflammatory or immune-mediated causes.<\/li>\n<li><strong>Diuretics<\/strong> (e.g., furosemide) help increase calcium excretion through urine.<\/li>\n<li><strong>Calcitonin<\/strong> can be used in severe cases to lower calcium levels temporarily.<\/li>\n<\/ul>\n<h4><strong>4. Treating Underlying Conditions<\/strong><\/h4>\n<ul data-spread=\"false\">\n<li><strong>Surgical Removal of Parathyroid Tumors<\/strong> \u2013 In cases of hyperparathyroidism, surgery may resolve hypercalcemia.<\/li>\n<li><strong>Cancer Treatment<\/strong> \u2013 Chemotherapy, radiation, or surgical removal of tumors can help control calcium levels.<\/li>\n<li><strong>Infection Management<\/strong> \u2013 If granulomatous disease is the cause, antifungal or antibiotic treatment may be necessary.<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-7515 size-full\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/01\/Petworks-Pet-Care-Service-Pro-Tips-e1736622469982.png\" alt=\"Hypercalcemia In Cats\" width=\"120\" height=\"120\" \/>\u201cHypercalcemia in dogs and cats. This usually indicates an underlying disease process causing the dysregulation of calcium homeostasis; clinical signs may or may not be evident.\u201d &#8211; <span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.merckvetmanual.com\/authors\/ham-kathleen\">Kathleen Ham, DVM, MS (Merck Veterinary Manual)<\/a><\/span><\/p>\n<h3 data-pm-slice=\"1 3 []\"><strong>Prognosis and Long-Term Management<\/strong><\/h3>\n<p>The prognosis for hypercalcemia depends on the underlying cause and how quickly treatment is initiated. Cats with idiopathic hypercalcemia can often be managed with dietary changes and medications. However, conditions like lymphoma or advanced kidney disease may have a more guarded prognosis.<\/p>\n<p>Regular veterinary check-ups, blood work, and monitoring calcium levels are essential for long-term management. In some cases, lifelong treatment is required to prevent complications.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-6834 size-full\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/12\/petworks-logo-article-e1734545691243.png\" alt=\"Hypercalcemia In Cats\" width=\"704\" height=\"131\" srcset=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/12\/petworks-logo-article-e1734545691243.png 704w, https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/12\/petworks-logo-article-e1734545691243-300x56.png 300w, https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/12\/petworks-logo-article-e1734545691243-640x119.png 640w\" sizes=\"auto, (max-width: 704px) 100vw, 704px\" \/><\/p>\n<p data-pm-slice=\"1 3 []\"><span style=\"color: #000080;\"><em><strong>Are you finding this article useful?<\/strong> <\/em>Would you like 100% free access to more articles like these, and free access to <span style=\"text-decoration: underline;\"><a style=\"color: #000080; text-decoration: underline;\" href=\"https:\/\/www.petworks.com\/request_quote\">over 5,000 vetted pet care service professionals<\/a><\/span> throughout the United States? <span style=\"text-decoration: underline;\"><a style=\"color: #000080; text-decoration: underline;\" href=\"https:\/\/www.petworks.com\/join\">Sign up here <\/a><\/span>for a free Petworks account, and we&#8217;ll email you a\u00a0 10% discount code, good towards your first pet care services booking on Petworks!<\/span><\/p>\n<h3><strong>Preventing Hypercalcemia in Cats<\/strong><\/h3>\n<p>While not all causes of hypercalcemia are preventable, as a cat owner, you can take proactive steps to minimize risks:<\/p>\n<ul data-spread=\"false\">\n<li>Avoid excessive vitamin D supplementation unless prescribed by a vet.<\/li>\n<li>Keep rodenticides and toxic substances out of reach.<\/li>\n<li>Provide a balanced diet tailored to your cat\u2019s specific health needs.<\/li>\n<li><span style=\"font-size: 1rem;\">Schedule regular veterinary check-ups to detect early signs of illness.<\/span><\/li>\n<\/ul>\n<p data-pm-slice=\"1 1 []\">Hypercalcemia in cats is a serious condition that requires prompt diagnosis and treatment. Understanding the potential causes, recognizing symptoms early, and working closely with a veterinarian can improve a cat\u2019s quality of life. With appropriate medical care and long-term management, many cats with hypercalcemia can lead comfortable lives.<\/p>\n<!--[if lt IE 9]><script>document.createElement('audio');<\/script><![endif]-->\n<audio class=\"wp-audio-shortcode\" id=\"audio-9806-1\" preload=\"none\" style=\"width: 100%;\" controls=\"controls\"><source type=\"audio\/mpeg\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/09\/169-Old-Redding-Rd-22.m4a?_=1\" \/><a href=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/09\/169-Old-Redding-Rd-22.m4a\">https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2024\/09\/169-Old-Redding-Rd-22.m4a<\/a><\/audio>\n<h3 data-start=\"7576\" data-end=\"7805\"><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.petworks.com\/infos\/about\">About Petworks<\/a><\/span><\/h3>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-7722\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/01\/Dr-Marty-Goldstein-Natures-Blend-Petworks-Nutrition.png\" alt=\"Dr Marty Goldstein Nature's Blend - Petworks Nutrition\" width=\"111\" height=\"109\" \/>In 2021, Dr. <span style=\"text-decoration: underline;\"><a style=\"text-decoration: underline;\" href=\"https:\/\/www.petworks.com\/articles\/dr-marty-goldstein-of-petworks\/\">Marty Goldstein DVM<\/a><\/span> joined the pet care platform Petworks as an advisor in its <span style=\"text-decoration: underline;\"><a style=\"text-decoration: underline;\" href=\"https:\/\/www.petworks.com\/hire\/animal-nutritionist\">Animal Nutrition<\/a><\/span>\u00a0care division. Dr Marty Nature&#8217;s Blend is\u00a0on a mission to help your pets live their healthiest lives possible.\u00a0Dr. Marty\u2019s pet nutrition expertise and guidance has helped Petworks evolve and become the preeminent animal and pet nutrition consultation service for pet\u00a0parents in North America.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-8658\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/01\/William-Bishop-Jr-Petworks-Pet-Nutrition.png\" alt=\"Bill Bishop Blue Buffalo Pet Nutrition\" width=\"96\" height=\"99\" \/>In 2022, <span style=\"text-decoration: underline;\"><a style=\"text-decoration: underline;\" href=\"https:\/\/www.petworks.com\/articles\/blue-buffalo-dog-food\/\">Blue Buffalo<\/a><\/span> Founder Bill Bishop Jr. joined Petworks as Senior Advisor in our Animal Nutrition Care Division. Bill brings his extensive expertise in pet food innovation and business leadership. His guidance helps Petworks enhance our pet nutrition service offerings, helping to ensure that pet parents throughout the world receive trusted, science-backed nutritional support for their dogs, cats, and animals.<\/p>\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p><span style=\"text-decoration: underline;\">About The Author<\/span><\/p>\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p><a href=\"https:\/\/www.petworks.com\/\"><span style=\"text-decoration: underline;\"><em><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-full wp-image-10642\" src=\"https:\/\/www.petworks.com\/articles\/wp-content\/uploads\/2025\/02\/Kevin-Kinyon-2025.jpeg\" alt=\"\" width=\"91\" height=\"108\" \/><\/em>Petworks<\/span><\/a> Co-Founder <a href=\"https:\/\/www.linkedin.com\/in\/kinyonkevin\/\"><span style=\"text-decoration: underline;\">Kevin Kinyon<\/span><\/a> is a life-long animal lover who works tirelessly to improve the lives of pets and their parents. Human and animal qualities he values most are integrity, humor, and empathy.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Understanding Hypercalcemia in Cats: Causes, Symptoms, Diagnosis, and Treatment. Hypercalcemia in cats is a condition characterized by elevated calcium levels in the bloodstream. While calcium is essential for various bodily functions, excessive levels can lead to serious health complications. Understanding the causes, symptoms, diagnosis, and treatment options for hypercalcemia is crucial for cat owners to &hellip; <\/p>\n<p class=\"link-more\"><a href=\"https:\/\/www.petworks.com\/articles\/hypercalcemia-in-cats\/\" class=\"more-link\">Read More<span class=\"screen-reader-text\"> &#8220;What Are The Signs Of Hypercalcemia In Cats?&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":9813,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[133],"tags":[],"class_list":["post-9806","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cat-behavior"],"jetpack_publicize_connections":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v25.3.1) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What Are The Signs Of Hypercalcemia In Cats?<\/title>\n<meta name=\"description\" content=\"Hypercalcemia in cats is a condition characterized by elevated calcium levels in the bloodstream. 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